It's one of the best choices available if you want to play Duke with some good classical look without having a serious eye-ache. I haven't personally tried a multiplayer capabilities of these port, but same as JFDuke3D, Eduke3D should allow this.
This port has a pretty standard installation interface, so there is no need in thorough instructions. The only thing to mention is: don't forget to choose a Dukester support if you want to use Dukester software for multiplayer games support.
Install port's files into your Duke3D game directory.
Ensure to start EDuke32 configuration from "Start->Programs->EDuke32->Setup".
Open 'Music, Sound and Video' section. Adjust 'voices', 'sample size', 'sample rate' and 'video resolution' to the maximum values supported by your hardware. I really doubt that this can seriously affect a perfomance on modern computers.
Configure mouse and keyboard assignments in 'Input devices' window.
Save configuration and run EDuke32.
Startup screen will appear, asking if you would like to enable a texture cache. Doesn't seem to make any difference on performance though.
Check that all checkboxes with simple options listed don't need any changes and that GRP file is found by Eduke32 successfully. Click 'Start' to start playing.
You can also adjust the in-game video settings to improve a texture filtration quality.
Looks like this port also supports High-Res textures and models. If somebody needs help with these features in this concrete port, please contact me, so I will investigate it with more caution.
Looks like this port should be fully playable. Didn't have a chance to try any of the Eduke's specific mods though.